| Popis: |
Acute ST-segment elevation myocardial infarction (ASTEMI) leads to great morbidity and mortality, even after immediate reperfusion therapy by primary percutaneous coronary intervention (PCI). Plasma exosomal proteins detected in the acute stage are supposed to affect the outcomes of ASTEMI. The present study collected ASTEMI patients with ischemic time around 6 hours and underwent successful emergency PCI, used exosomal proteomics to identify the plasma exosomal proteins, and performed a 1-year follow-up on ASTEMI outcomes. We observed that plasma exosomes concentration significantly decreased in ASTEMI after PCI than before it. Receiver operating characteristic (ROC) curve analysis revealed that several plasma exosomal proteins detected were strong predictors for coronary reintervention, which were revalidated in Cox regressions; while several plasma exosomal proteins were strong predictors for heart failure, which were revalidated in logistic regressions. The protein–protein network interactions and literature review suggest that plasma exosomal proteins might correlate with ASTEMI prognosis though involving in lipid and carbohydrate metabolism, regulation of cardiac muscle contraction, inflammation, platelet activation, or ferroptosis. Our results provide potential preventive and therapeutic targets for ASTEMI outcomes after PCI. |
