Cardiac Structural Alterations of Acromegalic, Without Alteration in Cardiac Function, Evaluated by Doppler Echocardiography with Speckle Tracking
| Autor: | Beatriz Pires Ferreira, Maria Candida Calzada Borges, Adriana Paula da Silva, Marília Matos Oliveira, José de Oliveira Ferreira, Maria de Fátima Borges, Beatriz Hallal Jorge Lara, Janaíne Machado Tomé |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cardiac function curve
education.field_of_study medicine.medical_specialty Ejection fraction medicine.diagnostic_test business.industry Population General Medicine Doppler echocardiography medicine.disease Internal medicine Acromegaly medicine Cardiology End-diastolic volume education business End-systolic volume Cause of death |
| Zdroj: | Global Journal of Health Science. 13:32 |
| ISSN: | 1916-9744 1916-9736 |
| DOI: | 10.5539/gjhs.v13n10p32 |
| Popis: | BACKGROUND: Acromegaly is most commonly caused by growth hormone secreting pituitary (GH) macroadenoma. Cardiovascular events are the leading cause of death in this population. OBJECTIVE: To analyze the cardiac structural and functional changes in patients with acromegaly and to correlate the findings with the concentrations of GH and IGF-1 post treatment and with the presumed time of disease. METHOD: A quantitative study involving 19 individuals with acromegaly, 10 with inactive disease and 9 with active disease and 16 healthy individuals, matched by sex and age. Age ranged from 19 to 78 years. Two-dimensional echocardiogram and speckle tracking were performed. RESULTS: Mean left ventricular mass index (LVMI) were significantly higher in acromegalic patients (89.1 ± 27.9) compared to the control group (66.9 ± 15.7) (p = 0.015). There was a direct correlation between IGF-1 mean concentration and left ventricular systolic volume (LVSV) in acromegalic patients (r = 0.64; p = 0.004) even when the disease was inactive (n=10; r = 0.9; p = 0.002) and between IGF1 mean concentration and left ventricular diastolic volume (LVDV). The left ventricular ejection fraction (EF) and the global longitudinal strain (GLS) did not differ between groups (p> 0.05). CONCLUSION: Although patients with acromegaly had higher LVMI, they did not show difference in GLS indicating a small chance of progression to systolic disfunction. Direct correlation between IGF-1 and LDVD and LVSV demonstrates the relevance of a good hormonal control to reduce cardiac changes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|