FermentedCordyceps militarisExtract Ameliorates Hepatosteatosis via Activation of Fatty Acid Oxidation
| Autor: | Young Jun Kim, Dong Ki Park, Tae-Sik Park, Hye-Jin Park, Nguyen Khoi Song Tran, Goon-Tae Kim, Do Yup Lee |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Nutrition and Dietetics Sphingosine Cordycepin biology Coenzyme A Fatty liver food and beverages Medicine (miscellaneous) medicine.disease biology.organism_classification 03 medical and health sciences Oleic acid chemistry.chemical_compound 0302 clinical medicine chemistry Biochemistry 030220 oncology & carcinogenesis Lipid droplet Cordyceps militaris medicine lipids (amino acids peptides and proteins) Beta oxidation |
| Zdroj: | Journal of Medicinal Food. 22:325-336 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2018.4245 |
| Popis: | Nonalcoholic fatty liver disease is a progressive disease involving the accumulation of lipid droplets in the liver. In this study, we investigated the anti-hepatosteatosis effects of fermented Cordyceps militaris extract (CME) in AML-12 hepatocytes. Although the levels of adenosine and cordycepin were reduced in the extracts of CM grown on germinated soybean (GSCE) and fermented CM grown on germinated soybean (GSC) by Pediococcus pentosaceus ON188 (ON188E), the expression of fatty acid oxidation (FAO) genes were upregulated only by GSC-ON188E treatment in a dose-dependent manner. In contrast, a lipogenic gene, stearoyl Coenzyme A desaturase 1, was downregulated by ON188E. Formation of intracellular lipid droplets by the addition of oleic acid was reduced by ON188E to levels observed in WY14643-treated cells. When cells were treated with ON188E, sphingosine kinase 2 mainly responsible for hepatic sphingosine 1-phosphate (S1P) synthesis was upregulated and S1P was elevated. Collectively, the fermented GSC extract activates FAO through elevation of S1P synthesis and has potential as a therapeutic for hepatosteatosis. |
| Databáze: | OpenAIRE |
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