Preparation of Biocompatible Composites based on Poly-L-Lactide/Hydroxyapatite and Investigation of their Anti-Inflammatory Activity
| Autor: | Irina Kurzina, D.N. Lytkina, L. A. Rasskazova, N. M. Korotchenko, I. V. Zhuk, Julia Kzhyshkowska, A. G. Filimoshkin, Yelena Shapovalova, Alexandru Gudima |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility medicine.drug_class 020502 materials Mechanical Engineering Composite number New materials 02 engineering and technology 021001 nanoscience & nanotechnology Biocompatible material Anti-inflammatory In vitro chemistry.chemical_compound 0205 materials engineering Polylactic acid chemistry Mechanics of Materials Poly-L-lactide medicine General Materials Science Composite material 0210 nano-technology Biomedical engineering |
| Zdroj: | Key Engineering Materials. 683:475-480 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.683.475 |
| Popis: | Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of anti-inflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites |
| Databáze: | OpenAIRE |
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