KETOGENIC AND ADIPOKINETIC ACTIVITIES OF PITUITARY HORMONES1

Autor:	Harry T. McPherson, Mildred G. Engel, Frank L. Engel
Rok vydání:	1957
Předmět:	medicine.medical_specialty medicine.medical_treatment Fatty liver Lipid metabolism Stimulation Biology medicine.disease Steroid Endocrinology Internal medicine Pituitary hormones medicine Secretion Ketosis Cortisone medicine.drug
Zdroj:	Endocrinology. 61:713-723
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-61-6-713
Popis:	IT HAS been known for many years that alkaline extracts of pituitary glands are capable of stimulating both ketosis and the development of fatty liver in various species. With the purification of pituitary hormones the evidence became increasingly suggestive that growth hormone was the factor which was responsible for the observed effects of pituitary extracts on fat metabolism. (For review of literature see references 1, 2, 3). From time to time irregular ketogenic responses to ACTH were reported and these were presumed to be due to the influence of adrenal cortical steroids (4, 5, 6, 7, 8, 9). However, doubt was cast on the latter interpretation by the demonstration that cortisone and cortisol inhibited fasting and other types of ketosis (10, 11, 12, 13). Moreover, when ACTH was administered to man by a slow intravenous drip which would be expected to cause maximal stimulation of adrenal cortical steroid secretion, fasting ketosis was suppressed (10).
Databáze:	OpenAIRE
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