Ligand-accelerating low-loading copper-catalyzed effective synthesis of (E)-1,3-enynes by coupling between vinyl halides and alkynes performed in water

Autor:	Peng Sun, Linhua Lu, Guangwei Rong, Jincheng Mao, Defu Liu, Hong Yan
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Ligand Chemistry Aryl halide Organic Chemistry Sonogashira coupling Halide Conjugated system Biochemistry Catalysis Coupling (electronics) Drug Discovery Polymer chemistry Copper catalyzed
Zdroj:	Tetrahedron. 69:6969-6974
ISSN:	0040-4020
DOI:	10.1016/j.tet.2013.06.063
Popis:	The useful conjugated enynes could be easily prepared via low-loading (0.0001 mol %) copper-catalyzed coupling between vinyl halides and terminal alkynes. It is noteworthy that this reaction could be preformed in water without using any co-solvents and the desired 1,3-enynes could be obtained with good yields. In the catalytic reaction, ligand-acceleration effect was markable.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::298684f05e54741d06860e05d83c71ab https://doi.org/10.1016/j.tet.2013.06.063 Zobrazit plný text záznamu Full Text from ScienceDirect