| Autor: |
Eduardo H Moretti, Abner C Rodrigues, Bruno V Marques, Leonardo T Totola, Caroline B Ferreira, Camila F Brito, Caroline M Matos, Filipe A da Silva, Robson A S Santos, Luciana B Lopes, Thiago S Moreira, Eliana H Akamine, Luiz A Baccala, André Fujita, Alexandre A Steiner |
| Rok vydání: |
2023 |
| Zdroj: |
PNAS Nexus. 2 |
| ISSN: |
2752-6542 |
| Popis: |
Uncontrolled vasodilation is known to account for hypotension in the advanced stages of sepsis and other systemic inflammatory conditions, but the mechanisms of hypotension in earlier stages of such conditions are not clear. By monitoring hemodynamics with the highest temporal resolution in unanesthetized rats, in combination with ex-vivo assessment of vascular function, we found that early development of hypotension following injection of bacterial lipopolysaccharide is brought about by a fall in vascular resistance when arterioles are still fully responsive to vasoactive agents. This approach further uncovered that the early development of hypotension stabilized blood flow. We thus hypothesized that prioritization of the local mechanisms of blood flow regulation (tissue autoregulation) over the brain-driven mechanisms of pressure regulation (baroreflex) underscored the early development of hypotension in this model. Consistent with this hypothesis, an assessment of squared coherence and partial-directed coherence revealed that, at the onset of hypotension, the flow–pressure relationship was strengthened at frequencies ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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