Investigation of CsCl-induced aggregation of serum albumin depending on pH by Raman spectroscopy method
| Autor: | Alexander M. Saletsky, I. M. Vlasova, V E Mikrin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Chromatography Physics and Astronomy (miscellaneous) biology Serum albumin Albumin Salt (chemistry) Human serum albumin Amino acid Metal symbols.namesake Isoelectric point chemistry visual_art visual_art.visual_art_medium symbols biology.protein medicine Raman spectroscopy Instrumentation medicine.drug |
| Zdroj: | Laser Physics Letters. 2:204-207 |
| ISSN: | 1612-202X 1612-2011 |
| DOI: | 10.1002/lapl.200410159 |
| Popis: | The evidence of human serum albumin aggregation at the presence of heavy metal salt (CsCl) is obtained by the Raman spectroscopy method. It is shown, that the strongest aggregation of albumin takes place near to albumin isoelectric point (at pH 5.0). Also the amino acidic mechanism of aggregation is explained, and aggregating chemical bonds arising between residues of amino acids are found out. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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