Modification of type I collagen on TiO2 surface using electrochemical deposition
| Autor: | Huynh Cong Nhat Nam, Vo Minh Thuy, Vo Van Toi, Nguyen Thanh Truc, Nguyen Thi Hiep, Ly Loan Khanh, Ho Hieu Minh, Tran Van Man, Tran Ngoc Quyen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science Scanning electron microscope medicine.medical_treatment chemistry.chemical_element 02 engineering and technology Osseointegration 03 medical and health sciences Materials Chemistry medicine Composite material Fibroblast Dental implant Surfaces and Interfaces General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Polyelectrolyte Surfaces Coatings and Films 030104 developmental biology medicine.anatomical_structure chemistry 0210 nano-technology Abutment (dentistry) Type I collagen Titanium |
| Zdroj: | Surface and Coatings Technology. 344:664-672 |
| ISSN: | 0257-8972 |
| DOI: | 10.1016/j.surfcoat.2018.03.038 |
| Popis: | Titanium (Ti) abutment is a supporting structure of dental implant which anchors and provides retention for fixed or removable tooth restoration. However, bio-inert property of Ti leaves the soft tissue to detach from the abutment, partly leading to implant failure. Meanwhile previous studies have mainly focused on enhancing the osseointegration of Ti implant, the dislocation and imbalance of dental implant still occur since the connective tissue defect at the abutment. This study aimed to investigate the interaction between fibroblast and the modified Ti in which type 1 collagen (Col-1) was modified on Ti surface. Ti/Col-1 modification was performed by electrochemical deposition (ECD) based on the polyelectrolyte property of Col-1 and conductivity of Ti under electric field. Parameters optimized for ECD were investigated including Col-1 concentration, pH of electrolyte, and deposition potential. Fibroblast's cell adhesion/spreading, and cell viability/proliferation assays were analyzed between the coated Ti/Col-1 with optimized ECD conditions and uncoated Ti. Scanning Electron Microscope (SEM) observation indicated that Col-1 was modified successfully on Ti while fibroblast cell adhered and proliferated well in Ti/Col-1 compared with the uncoated Ti. This study suggested the influence of Col-1 modification on the attachment of fibroblast cells around the Ti abutment. |
| Databáze: | OpenAIRE |
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