Enantioselective reduction of σ-Symmetric bicyclo[3.3.0]octane-2,8-diones with baker's yeast

Autor:	Manabu Node, Kouichi Hosomi, T. Inoue, Mamoru Araki, Kiyoharu Nishide
Rok vydání:	1995
Předmět:	Inorganic Chemistry chemistry.chemical_compound Bicyclic molecule chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Total synthesis Physical and Theoretical Chemistry Catalysis Yeast Octane
Zdroj:	Tetrahedron: Asymmetry. 6:31-34
ISSN:	0957-4166
DOI:	10.1016/0957-4166(94)00344-b
Popis:	σ-Symmetric bicyclic diketones 8a-c were enantioselectively reduced with baker's yeast to give the chiral hydroxy ketones 7a-c in 74–;100% ee. The reduction product (+)-7a and (−)-7′c were shown to be the chiral intermediates for the total synthesis of cantabrenonic acids derivatives 3 and hirsutene (4), respectively. The subsequent transformation of (+)-7a gave the intermediate (+)-5 for the total synthesis of capnellenols (1, 2).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::29670b03332a8873ad48ace14d44c4b8 https://doi.org/10.1016/0957-4166(94)00344-b Zobrazit plný text záznamu Full Text from ScienceDirect