| Autor: |
Modou Oumy Kane, W Diatta, M Sene, F Ba, A S Diallo, K Diatta, F S Barboza, M Lèye, Alioune Dior Fall |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Journal of Physiology and Pharmacology Advances. 5:732 |
| ISSN: |
2251-7693 |
| DOI: |
10.5455/jppa.20150928091828 |
| Popis: |
The aim of this study was to determine whether an hydro-alcoolic extract of cloves of Allium sativum is able to induce a relaxant effect in the rat aorta and so the mechanism underlying this effect. Rat aortic rings were suspended in organ chambers for recording of changes in isometric forces. Rings with endothelium were incubated or not with L-Nitro Arginine Methyl Ester (L-NAME) to block NO synthase, before contraction with adrenalin and a concentration relaxation curve to the hydro-alcoolic extract. In some experiments, endothelium was removed before contraction with adrenalin and concentration relaxation to the extract. Prevent effect of the extract was determine with contraction curve to adrenaline in rings with and without endothelium incubated with the extract of Allium sativum. The hydro-alcoolic extract of Allium sativum induces a vasodilatatory effect in the rat aorta contracted with adrenalin. This effect is not endothelium-dependent and is not mediated by NO. Furthermore the extract incubated with aorta rings, is able to prevent the contraction induced by adrenalin. Allium sativum induces vascular relaxation which can explain the benefic effect of this plant in treatment of high blood pressure in Senegal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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