Higher levels of complement C3a (activated C3) are cross-sectionally associated with higher carotid media thickness and lower ankle-arm blood pressure index: The CODAM study
| Autor: | Elisabeth Hertle, Edith J. M. Feskens, Casper G. Schalkwijk, Carla J.H. van der Kallen, Stefan L.C. Geijselaers, Isabel Ferreira, Coen D.A. Stehouwer, Marleen M.J. van Greevenbroek |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Immunology Population Hematology medicine.disease Complement (complexity) Complement system Blood pressure medicine.anatomical_structure Subclinical atherosclerosis Diabetes mellitus Internal medicine medicine Cardiology Immunology and Allergy Anaphylatoxin cardiovascular diseases Ankle education business |
| Zdroj: | Immunobiology. 217:1174 |
| ISSN: | 0171-2985 |
| DOI: | 10.1016/j.imbio.2012.08.130 |
| Popis: | The complement system has been proposed to play a role in the development of cardiovascular disease (CVD) and diabetes. The aim of this study was to investigate the association of complement C3a, an anaphylatoxin generated upon complement C3 activation, with prevalent CVD and markers of subclinical atherosclerosis [i.e. carotid intimamedia thickness (cIMT) and ankle-arm blood-pressure index (AAIx)] in a diabetes-prone population. |
| Databáze: | OpenAIRE |
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