Identification of the impurities in 2,5-dimethoxy-4-ethylphenethylamine tablets by high performance liquid chromatography mass spectrometry-ion trap-time of flight
| Autor: | Minchao Wang, Yun Wei, Yaning Li, Aoxin Li, Hui Zheng |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Materials science General Chemical Engineering 010401 analytical chemistry General Engineering Analytical chemistry Element composition Mass spectrometry 01 natural sciences High-performance liquid chromatography 0104 chemical sciences Analytical Chemistry Mass 03 medical and health sciences Time of flight 0302 clinical medicine Qualitative analysis Impurity 030216 legal & forensic medicine Ion trap |
| Zdroj: | Analytical Methods. 8:8179-8187 |
| ISSN: | 1759-9679 1759-9660 |
| DOI: | 10.1039/c6ay02162j |
| Popis: | This paper illustrated the identification of relevant impurities in illegal drug 2,5-dimethoxy-4-ethylphenethylamine (2C-E) which can help to regulate this illegal drug and identify the source of their manufacture. Hybrid ion trap/time-of-flight mass spectrometry coupled with high performance liquid chromatography (LC/MS-IT-TOF) is used as an efficient and effective method for qualitative analysis. In this study, the fragment pathway of 2C-E was deduced after the LC-MSn determination of the 2C-E standard by LC/MS-IT-TOF. Ten impurities were detected in the 2C-E tablets using an optimized LC/MS-IT-TOF method. According to the exact mass data of MSn and the analysis of the element composition, the structures of ten impurities were identified. The synthetic route of the 2C-E tablets was proposed by analysis of these impurities. The established method is not only effective in identifying impurities, but also helps to identify the manufacturing source of this illegal drug. |
| Databáze: | OpenAIRE |
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