Prevalencia de hipotiroidismo y relación con niveles elevados de anticuerpos antiperoxidasa y yoduria en población de 35 y más años en Armenia. 2009-2010
| Autor: | Adolfo Bayona, Patricia Landázuri, Ángela L. Londoño, Marta L. Gallego |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases biology business.industry Thyroid disease Public Health Environmental and Occupational Health chemistry.chemical_element Iodine medicine.disease Thyroiditis Iodised salt Endocrinology chemistry Thyroid peroxidase Internal medicine medicine biology.protein Population study business Hormone Peroxidase |
| Zdroj: | Revista de Salud Pública. 13:998-1009 |
| ISSN: | 0124-0064 |
| DOI: | 10.1590/s0124-00642011000600012 |
| Popis: | Objectives Determining the prevalence of hypothyroidism and its interrelationship with peroxidase antibodies and high urinary iodine levels as a means for devising a set of recommendations for health authorities regarding the consumption of iodised salt and the early detection of thyroid disease. Methods 437 people in the municipality of Armenia (Quindio) participated in the study. ELISA tests were performed for free thyroxine, thyroid-stimulating hormone and thyroid peroxidase antibodies; a photocolorimetric analysis was carried out to determine urinary iodine levels. Results Hypothyroidism prevalence was 18.5%. Thyroid peroxidase antibodies were positive in 28.9% of the study population, with significantly higher prevalence amongst those with levels > 10 mIU/mL thyroid-stimulating hormone compared to 5.1 to 10 mIU/mL in those without it (OR 3.2) and smokers (O.R 3,4). Free thyroxine was normal in 98.2% of participants (> 5 mIU/mL thyroid-stimulating hormone levels) and 92% in those in whom > 10 mIU/mL thyroid-stimulating hormone levels were found. The average iodine level was 565.1; levels above 300µg/L were obtained in 81.8% of the participants. Conclusions Increased positive thyroid peroxidase antibody prevalence with increasing thyroid-stimulating hormone values could demonstrate a high risk of developing autoimmune hypothyroidism in Armenia; despite high iodine levels, a relationship with thyroid peroxidase antibodies or thyroid-stimulating hormone levels could not be established. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|