Effect of Paracetamol (Acetaminophen) On Haematological and Reproductive Parameters in Male Albino Rats

Autor:	Bolarinwa A. F, Oyedeji K. O
Rok vydání:	2013
Předmět:	business.industry digestive oral and skin physiology Analgesic Semen Pharmacology Sperm Acetaminophen Red blood cell medicine.anatomical_structure Blood chemistry White blood cell medicine business Sperm motility medicine.drug
Zdroj:	IOSR Journal of Pharmacy and Biological Sciences. 4:65-70
ISSN:	2278-3008 2319-7676
DOI:	10.9790/3008-0466570
Popis:	Paracetamol (acetaminophen) is a widely used over-the-counter analgesic and antipyretic drugs. Several studies have reported the toxic, gastrointestinal and musculoskeletal effect of this drug, but there is scanty information on its effect on blood chemistry and reproduction in albino rats. This study was designed to investigate the effect of this drug on haematological and reproductive parameters in male albino rats. Paracetamol (7.5 mg/kg BW) was administered to the rats for 42 days (six weeks) for haematological and andrological study. Distilled water (0.5 ml) served as control. Red Blood Cell (RBC) and Total White Blood Cell (TWBC) counts were determined using haemocytometer. PCV was determined by micro-haematocrit method. Semen analyses were done microscopically. Data were analysed using student’s t-test at p
Databáze:	OpenAIRE
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