Formulation and physical properties of thixotropic gels for hard gelatin capsules

Autor:	C. J. Taylor, J. T. Pearson, P. A. Walters, G. Rowley
Rok vydání:	1992
Předmět:	Pharmacology Active ingredient Thixotropy Materials science Stereochemistry Organic Chemistry Pharmaceutical Science Dosage form Colloidal Silicon Dioxide Hard gelatin capsules Chemical engineering Rheology Drug Discovery Drug release medicine Propantheline bromide medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 18:1613-1631
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049209040890
Popis:	Thixotropic gels for filling into hard gelatin capsules at room temperature were formulated using Miglyol 829 and colloidal silicon dioxide. Initial studies on several vehicles were undertaken prior to selection of Miglyol 829 for detailed study. The rheological properties of the gels and drug/gel formulations have been investigated in detail and the results are discussed with reference to capsule filling, stability and drug release of a model drug propantheline bromide (PPBr).
Databáze:	OpenAIRE
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