Recommended Iodine Dose for Multiphasic Contrast-Enhanced Mutidetector-Row Computed Tomography Imaging of Liver for Assessing Hypervascular Hepatocellular Carcinoma
| Autor: | Takamichi Murakami, Akiko Hayakawa, Kazuhito Shiosakai, Tomoaki Ichikawa, Kengo Yoshimitsu, Masahiro Okada, Kazuo Awai, Hiroshi Kondo, Masayuki Kanematsu, Yasuyuki Yamashita, Hironobu Sou, Shushi Yoshikawa |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry chemistry.chemical_element Computed tomography respiratory system medicine.disease Iodine chemistry Hepatic parenchyma Hepatocellular carcinoma medicine Radiology Nuclear Medicine and imaging Radiology Iohexol Nuclear medicine business Prospective cohort study medicine.drug |
| Zdroj: | Academic Radiology. 20:1130-1136 |
| ISSN: | 1076-6332 |
| Popis: | Rationale and Objectives To determine the recommended iodine dose of contrast material (CM) for hepatic arterial–dominant phase (HAP) and hepatic parenchymal phase (HPP) imaging to assess hypervascular hepatocellular carcinoma (HCC). Materials and Methods This was a prospective study including 348 patients with hypervascular HCC in 77 hospitals as a postmarketing surveillance to investigate the effects of body weight–tailored dose of CM (300 mgI/mL of iohexol) for hepatic multiphasic contrast-enhanced multidetector-row computed tomography imaging. Informed consent was obtained from all patients who were enrolled. The tumor-to-liver contrast (TLC) of HAP images was assessed qualitatively (QL-TLC) and quantitatively (QT-TLC [HU]; computed tomography [CT] value of tumor–CT value of hepatic parenchyma). Minimal and sufficient QT-TLC were defined as CT values corresponding to the median and 75% of QL-TLC assigned with “good,” respectively. The recommended iodine dose was estimated by the relationship between iodine dose (mgI/kg) and QT-TLC. Results There was a good correlation between QL-TLC and QT-TLC. The recommended iodine dose of CM for HAP imaging was considered to be in the range of 567–647 mgI/kg based on minimal (33.7 HU) and sufficient QT-TLC (40.9 HU). Meanwhile, the recommended dose of CM for HPP imaging was 572 mgI/kg as a dose that gives hepatic enhancement more than 50 HU during HPP imaging. Conclusions The recommended iodine dose of CM for HAP and HPP imaging may be different, being 567–647 mgI/kg and 572 mgI/kg, respectively, in assessing hypervascular HCC. |
| Databáze: | OpenAIRE |
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