Chemotherapeutic Treatments with Time Increasing Mutation Rate to Drug Resistance
| Autor: | José Luiz Boldrini, M. I. S. Costa |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Drug
Chemotherapy Mutation rate Ecology Applied Mathematics medicine.medical_treatment Optimal treatment media_common.quotation_subject General Medicine Drug resistance Pharmacology Biology Agricultural and Biological Sciences (miscellaneous) Drug concentration System of differential equations medicine Tumor growth media_common |
| Zdroj: | Journal of Biological Systems. :49-62 |
| ISSN: | 1793-6470 0218-3390 |
| DOI: | 10.1142/s0218339097000059 |
| Popis: | A system of differential equations for the control of tumor growth cells in a cycle nonspecific chemotherapy is analyzed. Spontaneously acquired drug resistance is taken into account by means of a mutation rate increasingly dependent on time. For general tumor growth and drug kill rates the optimal treatment consists of maximum allowable drug concentration throughout, supporting the conjecture that variable mutation rate to drug resistance does not basically alter the corresponding results of constant mutation rate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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