| Popis: |
The use of plants as sources of drug agents is attributed by factors among which are the easy accessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditional medicine and drug discovery field necessitates investigation of pure compounds in any plant with medicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plant in Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis of ethanolic and methanolic extracts of root and stem barks respectively aided to isolated six pure compounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while their spectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was a phenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (β-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicity evaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practically non-toxic. |
