Solid-Phase Synthesis and Antibacterial Activity of an Artificial Cyclic Peptide Containing Two Disulfide Bridges
| Autor: | Bayan A. K. Haimur, Khalil K. Y. Saleh, Eyad Mallah, Moawiya A. Haddad, Samir A. Al-Taweel, Da’san M. M. Jaradat, Tawfiq Arafat, Karem H. Alzoubi, Basmah H. M. Za’arir |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Chemistry Magainin Bioengineering Peptide biology.organism_classification 01 natural sciences Biochemistry Proteus mirabilis Cyclic peptide 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound Solid-phase synthesis Drug Discovery Molecular Medicine Bioorganic chemistry Antibacterial activity Bacteria |
| Zdroj: | International Journal of Peptide Research and Therapeutics. 25:1095-1102 |
| ISSN: | 1573-3904 1573-3149 |
| DOI: | 10.1007/s10989-018-9757-y |
| Popis: | Synthesis of artificial antibacterial peptides containing multiple disulfide bridges is of particular interest in bioorganic chemistry. In this paper, a straightforward on-resin synthesis of a cyclic peptide containing two disulfide bridges by orthogonal protection approach is presented. This artificial peptide is a biomimetic peptide that has structural combination of Magainin and Defensins peptides at the same time. It showed antibacterial activity against a number of Gram-negative and Gram-positive bacteria including Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Staphylococcus aureus, and others with MICs between 10 and 35 µg/mL. In general, Gram-negative bacteria showed more susceptibility to this artificial peptide than Gram-positive bacteria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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