Probing n-Octyl α-d -Glycosides Using Deuterated Water in the Lyotropic Phase by Deuterium NMR
| Autor: | N. Idayu Zahid, Wan Farah Nasuha Wan Iskandar, Rauzah Hashim, Melonney Patrick, Bakir A. Timimi, Malinda Salim |
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| Rok vydání: | 2021 |
| Předmět: |
Deuterium NMR
010304 chemical physics Hydrogen bond Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Crystallography Deuterium Liquid crystal Phase (matter) 0103 physical sciences Lyotropic Materials Chemistry Molecule Bound water Physical and Theoretical Chemistry |
| Zdroj: | The Journal of Physical Chemistry B. 125:4393-4408 |
| ISSN: | 1520-5207 1520-6106 |
| Popis: | The lyotropic phase behavior of four common and easily accessible glycosides, n-octyl α-d-glycosides, namely, α-Glc-OC8, α-Man-OC8, α-Gal-OC8, and α-Xyl-OC8, was investigated. The presence of normal hexagonal (HI), bicontinuous cubic (VI), and lamellar (Lα) phases in α-Glc-OC8 and α-Man-OC8 including their phase diagrams in water reported previously was verified by deuterium nuclear magnetic resonance (2H NMR), via monitoring the D2O spectra. Additionally, the partial binary phase diagrams and the liquid crystal structures formed by α-Gal-OC8 and α-Xyl-OC8 in D2O were constructed and confirmed using small- and wide-angle X-ray scattering and 2H NMR. The average number of bound water molecules (nb) per headgroup in the Lα phase was determined by the systematic measurement of the quadrupolar splitting of D2O over a wide range of molar ratio values (glycoside/D2O), especially at high glucoside composition. The number of bound water molecules bound to the headgroup was found to be around 1.5-2.0 for glucoside, mannoside, and galactoside, all of which possesses four OH groups. In the case of xyloside, which has only three OH groups, the bound water content is ∼2.0. Our findings confirmed that the bound water content of all n-octyl α-d-glycosides studied is lower compared to the number of possible hydrogen bonding sites possibly due to the fact that most of the OH groups are involved in intralayer interaction that holds the lipid assembly together. |
| Databáze: | OpenAIRE |
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