α-Glucosidase Inhibitory and A Leptospermone Derivative from Rhodomyrtus tomentosa
| Autor: | Eliza Eliza, Ferlinahayati Ferlinahayati, Budi Untari, Daniel Alfarado |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
chemistry.chemical_classification Rhodomyrtus tomentosa Chromatography biology Butanol Ethyl acetate Leptospermone General Chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences Hexane 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Enzyme chemistry medicine Methanol 010606 plant biology & botany Acarbose medicine.drug |
| Zdroj: | Indonesian Journal of Chemistry. 20:307 |
| ISSN: | 2460-1578 1411-9420 |
| Popis: | One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC 50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n -butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC 50 13.49 and 19.29 μg/mL) compare to acarbose and n -hexane fraction (IC 50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC 50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|