Taurine Chloramine Inhibits Production of Inflammatory Mediators and iNOS Gene Expression in Alveolar Macrophages; a Tale of Two Pathways: Part II, IFN-γ Signaling Through JAK/Stat

Autor: Michael R. Quinn, Yong Liu, Valeria Serban, Madhabi Barua
Rok vydání: 2003
Předmět:
Zdroj: Advances in Experimental Medicine and Biology ISBN: 9781461349136
DOI: 10.1007/978-1-4615-0077-3_43
Popis: Taurine protects against tissue damage in a variety of models that share inflammation as a common pathogenic feature1. This has been particularly well documented in animal models of lung injury where prophylactic administration of taurine protects lung from damage induced by inhalation exposure to NO2 2 or 03 3 and by intratracheal instillation of bleomycin4,5, amidarone6, or paraquat7. Lung damage in these models is associated with an influx of neutrophils along with mononuclear leukocytes and production of inflammatory mediators, which contribute to the ensuant pulmonary damage.
Databáze: OpenAIRE