DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression
| Autor: | Terry L. Orr-Weaver, Brian L Hua |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DNA re-replication Genetics biology DNA replication Pre-replication complex 3. Good health DNA replication factor CDT1 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Licensing factor SeqA protein domain Control of chromosome duplication biology.protein Origin recognition complex 030217 neurology & neurosurgery |
| Zdroj: | Genetics. 207:29-47 |
| ISSN: | 1943-2631 |
| Popis: | Proper control of DNA replication is critical to ensure genomic integrity during cell proliferation. In addition, differential regulation of the DNA replication program during development can change gene copy number to influence cell size and gene expression. Drosophila melanogaster serves as a powerful organism to study the developmental control of DNA replication in various cell cycle contexts in a variety of differentiated cell and tissue types. Additionally, Drosophila has provided several developmentally regulated replication models to dissect the molecular mechanisms that underlie replication-based copy number changes in the genome, which include differential underreplication and gene amplification. Here, we review key findings and our current understanding of the developmental control of DNA replication in the contexts of the archetypal replication program as well as of underreplication and differential gene amplification. We focus on the use of these latter two replication systems to delineate many of the molecular mechanisms that underlie the developmental control of replication initiation and fork elongation. |
| Databáze: | OpenAIRE |
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