Quartz-Containing Ceramic Dusts:In vitroscreening of the cytotoxic, genotoxic and pro-inflammatory potential of 5 factory samples

Autor:	G. Attik, R. Brown, Otto Creutzenberg, Christina Ziemann, B H Rihn, P. Jackson
Rok vydání:	2009
Předmět:	History Materials science Inhalation Respirable Crystalline Silica Analytical chemistry Toxic potential In vitro Computer Science Applications Education visual_art visual_art.visual_art_medium Cytotoxic T cell Ceramic Quartz Nuclear chemistry
Zdroj:	Journal of Physics: Conference Series. 151:012022
ISSN:	1742-6596
DOI:	10.1088/1742-6596/151/1/012022
Popis:	Inhalation of some respirable crystalline silica (MMAD RF>TG>Ti>BR>TC>Al2O3. DNA-damage was maximal for BR and TI followed by DQ12>TG>TC>RF>Al2O3. All dusts induced PGE2-liberation (DQ12>BR>TC>TG>Ti>RF>Al2O3) at 50μg/cm2 (4h), but TNF-a mRNA (10μg/cm2, 24h) was only increased by DQ12, TG (quartz-dependently), and TC. In conclusion, these in vitro tests were an adequate approach to screen the toxic potential of quartz-containing ceramic dusts, but the quartz-content was too low to differentiate the various quartz-varieties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::290e26357f69af5d6a0377473a16aa07 https://doi.org/10.1088/1742-6596/151/1/012022 Zobrazit plný text záznamu