Comparison of the Modifying Action of Astaxanthin on the Development of Radiation-Induced Chromosome Instability in Human Blood Lymphocytes Irradiated in vitro at Different Cell Cycle Stages
| Autor: | D. A. Kurinnyi, O. M. Demchenko, S. R. Rushkovskyi, O. B. Dybska, M A Pilinska |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Human blood Radiation-induced chromosome instability Cell Biology Cell cycle Agricultural and Biological Sciences (miscellaneous) Molecular biology In vitro 03 medical and health sciences On cells chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Astaxanthin 030220 oncology & carcinogenesis Chromosome instability Genetics Irradiation |
| Zdroj: | Cytology and Genetics. 52:368-373 |
| ISSN: | 1934-9440 0095-4527 |
| DOI: | 10.3103/s0095452718050055 |
| Popis: | This study presents the results and comparison of the distinctive features of the modifying effect of astaxanthin (20.0 μg/mL) on γ-radiation-induced chromosomal instability in human peripheral blood lymphocytes that were irradiated in vitro (1.0 Gy) at the G0, S, and G2 stages of the cell cycle. The study showed that the effect of astaxanthin on cells irradiated at cell cycle stages S and G2 did not lead to changes in the mean frequencies and the spectrum of radiation-induced chromosomal aberrations (p > 0.05). A powerful protective effect of astaxanthin on the level of radiation-induced chromosomal instability (p < 0.001) was observed only in cells that were irradiated at the G0 stage. Thus, the dependence of the radioprotective effect of astaxanthin on the mitotic cycle stage at which the cells were exposed to radiation was established. |
| Databáze: | OpenAIRE |
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