| Popis: |
Thyrotoxic periodic paralysis (TPP) is a condition featuring attacks of muscle weakness in the presence of hyperthyroidism. Hypokalaemia is the hallmark of TPP. The condition may be life-threatening if there is weakness of respiratory muscles or cardiac arrhythmias. If hyperthyroidism is uncontrolled, TPP is recurrent in nature. The condition has been linked with genetic mutations or variants in certain ion channels that code for sodium and potassium across cell membranes. The main ones are the KCNJ family and L-type calcium channel alpha 1 subunit. The abnormality in these ion channels leads to shifts of potassium across cell membrane in hyperthyroid state. |
