The manipulability of what? The history of G-protein coupled receptors
| Autor: | Ann-Sophie Barwich, Karim Bschir |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cognitive science business.industry 05 social sciences Scientific realism 050905 science studies Object (philosophy) 03 medical and health sciences Philosophy Entity realism Philosophy of biology 030104 developmental biology History and Philosophy of Science Argument Chemistry (relationship) Artificial intelligence 0509 other social sciences General Agricultural and Biological Sciences business Psychology Central element |
| Zdroj: | Biology & Philosophy. 32:1317-1339 |
| ISSN: | 1572-8404 0169-3867 |
| DOI: | 10.1007/s10539-017-9608-9 |
| Popis: | This paper tells the story of G-protein coupled receptors (GPCRs), one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to conceptually coordinate measurable effects distinctly to a specific object. We show that a scientific entity, such as GPCRs, is assigned varying degrees of reality throughout different stages of its discovery. The criteria of its reality, we further claim, cannot be made independently of the question about how this object becomes a standard by which the reality of neighbouring elements of enquiry is evaluated. |
| Databáze: | OpenAIRE |
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