The cognitive aspect of formal thought disorder and its relationship with global social functioning and the quality of life in schizophrenia

Autor:	Esra Aki, Aygun Ertugrul, Hatice Abaoğlu, M Kazım Yazıcı, Elif Barışkın, Emre Mutlu, A. Elif Anıl Yağcıoğlu, S. Can Gurel
Rok vydání:	2021
Předmět:	Health (social science) Social Psychology medicine.diagnostic_test Positive and Negative Syndrome Scale Epidemiology Thought disorder Cognition Neuropsychological test medicine.disease Executive functions 030227 psychiatry Cognitive test 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Schizophrenia mental disorders medicine Verbal fluency test 030212 general & internal medicine medicine.symptom Psychology Clinical psychology
Zdroj:	Social Psychiatry and Psychiatric Epidemiology. 56:1399-1410
ISSN:	1433-9285 0933-7954
DOI:	10.1007/s00127-021-02024-w
Popis:	It was expected that using a comprehensive scale like the Thought and Language Disorder Scale (TALD) for measurement of FTD would enable assessing its heterogeneity and its associations with cognitive impairment and functionality. This study has aimed to analyze the relationship between formal thought disorder (FTD) and cognitive functions, functionality, and quality of life in schizophrenia. This cross-sectional exploratory study included 46 clinical participants meeting the DSM-5 diagnostic criteria for schizophrenia and 35 healthy individuals as the control groups. Data were acquired by means of the Turkish language version of the TALD, the Positive and Negative Syndrome Scale, the Clinical Global Impression Scale, the Functioning Assessment Short Test, the Social Functioning Scale, the World Health Organization Quality of Life Instrument-Short Form, and a neuropsychological test battery on executive functions, working memory, verbal fluency, abstract thinking, and response inhibition. Correlation analyses were conducted to detect significant relationships. The clinical group scored failures in all cognitive tests. The objective positive FTD was associated with deficits in executive functions and social functioning. The objective negative FTD was associated with poor performance in all cognitive domains, physical quality of life, and social and global functioning. The subjective negative FTD was negatively correlated with psychological quality of life. This study demonstrated that objective FTD factors reflect different underlying cognitive deficits and correlate with different functioning domains. Significant correlation was determined between subjective negative FTD and psychological quality of life. Given the close relationship of FTD with functioning and quality of life, the FTD-related cognitive deficits should be the key treatment goal in schizophrenia.
Databáze:	OpenAIRE
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