ChemInform Abstract: Synthesis and Anticonvulsant Activities of 5-(2-Chlorophenyl)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a] [1,4]diazepines

Autor:	Edward E. Knaus, Charles Fiakpui, Oludotun A. Phillips, K. S. Keshava Murthy
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Diazepine Trimethyl orthoformate Anticonvulsant chemistry Stereochemistry Triethyl orthoacetate Acid catalyzed medicine.medical_treatment Petit mal medicine General Medicine
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199940141
Popis:	A group of 5-(2-chlorophenyl)-10-(substituted)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepines 7a-c were synthesized by the acid catalyzed reaction of 5-(2-chlorophenyl)-2-hydrazino-3H-pyrido[3,4-e]-[1,4]diazepine (6) with either trimethyl orthoformate, triethyl orthoacetate or triethyl orthobenzoate, respectively. 5-(2-Chlorophenyl)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine (7a) and 5-(2-chlo-rophenyl)-10-methyl-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine (7b) exhibited good anticonvulsant activity in the subcutaneous metrazol anticonvulsant screen which serves as a model for absence (petit mal) epilepsy.
Databáze:	OpenAIRE
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