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The therapeutic irradiation for lung cancer causes profound disturbances of host's general immunocompetence, the cellular immunodepression being the dominant finding. It is thought that the split-course technique holds certain advantage over the continuous irradiation, since the former includes a period of 4 weeks between two courses, thus allowing the Iymphopoeitic system to recover to a certain degree. In this report, we compared the radiotherapy-due alterations of several cellular immunity parameters (the number and function of total T cells, active T cells and the cells of monocyte/macrophage lineage), immediately after the completion of either continuously (n = 13) or split course-irradiated (n = 12) lung cancer patients. All patients had received the total dose of 60 Gy. Both therapeutical techniques caused alterations of the parameters tested: the significant decrease of the total and active T cells and their lymphoproliferative response, while the phagocyting activity and the number of mononuclear phagocytes were increased, the latter being affected to a lesser extent in split-course-treated patients. Our results suggest that both techniques have similar immunodepressant effect on the cellular immunity of lung cancer patients. |
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