ChemInform Abstract: Selective Vinyl C-H Lithiation of cis-Stilbenes

Autor:	Anne-Marie L. Hogan, Thomas Tricotet, Carsten Strohmann, Donal F. O'Shea, Viktoria H. Gessner, Juliet Cotter, Patricia Fleming
Rok vydání:	2009
Předmět:	Chemistry Regioselectivity Stereoselectivity General Medicine Selectivity Combinatorial chemistry
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200928079
Popis:	A stereochemistry-controlled suppression of carbolithiation facilitated a regioselective vinyl C−H lithiation of cis-stilbenes allowing routine regio- and stereoselective access to polysubstituted alkenes and heterocycles. This unique selectivity was obtained for numerous directing groups and could be rationalized with DFT computational studies and an experimental mechanistic illustration of a unique anion migration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28de38ebde777716c1ebb6b4b7e56e03 https://doi.org/10.1002/chin.200928079 Zobrazit plný text záznamu Plný text