Antifungal activity of new derivatives of 4-(het)aryl-2,4-dioxobutanoic acids

Autor:	Fedor V. Sobin, Пулина Наталья Алексеевна (Ru), Natalya A. Pulina, Konstantin V. Lipatnikov, Valentina V. Novikova
Rok vydání:	2020
Předmět:	Antifungal biology Serial dilution Chemistry medicine.drug_class Aryl General Medicine Liquid medium biology.organism_classification Yeast Microbiology chemistry.chemical_compound Candida spp medicine Candida albicans Pathogen
Zdroj:	Reviews on Clinical Pharmacology and Drug Therapy. 18:225-228
ISSN:	2542-1875 1683-4100
Popis:	Among more than 600 types of micromycetes of clinical importance, fungi of the Candida spp. are the most common pathogen, causing different forms of candidiasis (superficial candidiasis, visceral candidiasis). The aim of this work was to determine the antifungal activity of new derivatives of 4-(het)aryl-2,4-dioxobutanoic acids, in relation to typical strains of Candida yeast and to identify the most active compounds. The study of the antifungal activity of the compounds was carried out by the micromethod of double serial dilutions in a liquid medium. The antifungal activity of 6 compounds in relation to 4 typical strains of Candida spp. was studied; the high antimycotic activity of 4 compounds against the Candida albicans strain was established. A leader compound with high antifungal activity for all the studied strains was revealed. The prospects of studying the modified compounds of this series are shown.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28db0197e285e9b2ee9da0fce38a88f3 https://doi.org/10.17816/rcf183225-228 Zobrazit plný text záznamu