Fabrication and improvement of PCL/alginate/PAAm scaffold via selective laser sintering for tissue engineering
| Autor: | Jinzhe Wu, Xiaoying Liu, Jinjin Zheng, Runhuai Yang, Linxin Pan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Fabrication Materials science Polyacrylamide Biomedical Engineering Bioengineering macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention chemistry.chemical_compound Tissue engineering law General Materials Science Elastic modulus technology industry and agriculture musculoskeletal system equipment and supplies 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Selective laser sintering chemistry Polycaprolactone Polymer blend 0210 nano-technology Biomedical engineering |
| Zdroj: | Micro & Nano Letters. 14:852-855 |
| ISSN: | 1750-0443 |
| Popis: | In this work, porous polycaprolactone (PCL) scaffolds were designed and fabricated using selective laser sintering (SLS). The critical processing parameters of the SLS for PCL were optimised. This work post-processed these PCL scaffolds to produce PCL/alginate/polyacrylamide (PAAm) scaffolds to improve their performance. The experiment mechanical property assessment showed that the sample's average elastic modulus increases from 6.99 MPa (PCL) to 12.67 MPa (PCL/alginate/PAAm), and the elongation at break of samples increases from 59% (PCL) to 112.9% (PCL/alginate/PAAm). Cell seeding and in vitro culture showed that cell viability remained above 94% over 5 days. Thus, the current study suggests that a promising strategy for the improvement of the characteristics of PCL/alginate/PAAm scaffolds and advances the potential application of SLS technique towards skeletal tissue repair. |
| Databáze: | OpenAIRE |
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