| Autor: |
Mark B. Cannell, W. Jonathan Lederer, Paulo Kofuji, A E Doering, Dan H. Schulze, Ernst Niggli, Peter Lipp, C. Valdivia, R. S. Kieval, Heping Cheng |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Developments in Cardiovascular Medicine ISBN: 9789401057653 |
| DOI: |
10.1007/978-94-011-3990-8_39 |
| Popis: |
The Na+/Ca2+ exchanger was first identified nearly three decades ago in heart [1] and in nerves [2]. It has been identified in virtually every tissue by functional tests or by molecular or immunological techniques [3–12]. The Na+/Ca2+ exchanger is located in the plasma membrane and serves to extrude calcium from the cytosolic compartment. Nevertheless, it can transport ions in either direction. The direction of transport depends on the electrochemical gradient for sodium and calcium ions across the plasmalemmal membrane since the Na+/Ca2+ exchanger uses the electrochemical gradients to power its transport activity. It transports three sodium ions in one direction and counter-transports one calcium ion (in the opposite direction). Consequently, a net positive charge moves in the direction of sodium transport and transport of sodium and calcium by the Na+/Ca2+ exchanger is both voltage-sensitive and electrogenic [3,4,13]. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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