Anti-Inflammatory Effects of H aliotis discus hannai Ino on Dextran Sulfate Sodium-Induced Colitis in Mice

Autor:	Trishna Debnath, Da Hye Kim, Young Ock Kim, Han Jong Pyo, Jeong Jun Lee, Beong Ou Lim, Mohammad Al Mijan, Jeong Eun Jo
Rok vydání:	2015
Předmět:	Pharmacology Abalone medicine.drug_class Activator (genetics) Crypt Biophysics Cell Biology Biology medicine.disease biology.organism_classification Ulcerative colitis Anti-inflammatory Proinflammatory cytokine Immunology medicine Haliotis discus Colitis Food Science
Zdroj:	Journal of Food Biochemistry. 39:209-217
ISSN:	0145-8884
DOI:	10.1111/jfbc.12118
Popis:	In this study, an ethanol extract (HDE1) and a fermented extract (HDE2) of Haliotis discus hannai Ino (Pacific abalone) were administered to mice with dextran sulfate sodium (DSS)-induced colitis. Both extracts were administered at 50 mg/kg and evaluated for their anti-inflammatory effects. Histological evaluations indicated that HDE1 effectively suppressed colonic tissue damage in mice with DSS-induced colitis. In addition, the expression levels of immune-related cytokines and transcription factors such as interferon-γ (IFN-γ), phosphorylated signal transducer and activator of transcription-1 (pSTAT1), interleukin-4 (IL-4), phosphorylated signal transducer and activator of transcription-6 (pSTAT6) and Gata3 were also downregulated by both extracts. These results indicated that both HDE1 and HDE2 suppressed inflammatory cytokines and mediators. However, histological examinations clearly suggested that HDE1 had greater efficacy in attenuating colonic tissue damage by DSS than HDE2. Therefore, HDE1 may be a potential anti-inflammatory agent for the treatment of ulcerative colitis. Practical Applications Pacific abalone is an important marine food source in many Asian countries. The health benefits of Pacific abalone have been demonstrated in a number of studies. This study investigated the anti-inflammatory effects of Pacific abalone extracts in a mouse model of ulcerative colitis. An ethanol extract (HDE1) of Pacific abalone potently suppressed the mucosal tissue damage and crypt loss in the colons of mice exposed to DSS. In addition, inflammatory cytokines and mediators were effectively suppressed by HDE1. Therefore, HDE1 may be a potential therapy for ulcerative colitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28a77e5442a84b0afa74694f9cedfccd https://doi.org/10.1111/jfbc.12118 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.