Increased soluble ST2 predicts long-term mortality in patients with stable coronary artery disease

Autor:	Marcus E. Kleber, Hubert Scharnagl, M. Haltmayer, B. Dieplinger, Winfried Maerz, Tanja B. Grammer, T. Mueller, Guenther Silbernagel, M. Egger
Rok vydání:	2013
Předmět:	medicine.medical_specialty Ejection fraction business.industry medicine.disease Surgery Coronary artery disease Quartile Heart failure Diabetes mellitus Relative risk Internal medicine Cohort medicine Cardiology Myocardial infarction Cardiology and Cardiovascular Medicine business
Zdroj:	European Heart Journal. 34:2778-2778
ISSN:	1522-9645 0195-668X
DOI:	10.1093/eurheartj/eht309.2778
Popis:	Background: Soluble ST2 (sST2) has emerged as a strong prognostic biomarker in patients with heart failure and myocardial infarction. There is no published data on sST2 in patients with stable coronary artery disease (CAD). Therefore, the aim of this study was to evaluate the long-term prognostic value of sST2 in patients with stable CAD. Methods: sST2 plasma concentrations were measured in 1345 patients with stable CAD referred to coronary angiography at a single tertiary care center. The primary enpoint was all-cause mortality. Results: During a median follow-up time of 9.8 years, 477 (36%) patients died. The median sST2 plasma concentration at baseline was significantly higher among decedents than survivors (21.4 vs. 18.5 U/mL; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28a68a2a364dafa6a44e4f539c051781 https://doi.org/10.1093/eurheartj/eht309.2778 Zobrazit plný text záznamu