The efficacy and safety of Urtica dioica in treating benign prostatic hyperplasia: a systematic review and meta-analysis
| Autor: | Maimaiti Aiyireti, Meng Wang, Yuanshan Cui, Changping Men |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Gynecology
medicine.medical_specialty business.industry 030232 urology & nephrology Urology medicine.disease Placebo law.invention 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Complementary and alternative medicine Randomized controlled trial Strictly standardized mean difference law Prostate Lower urinary tract symptoms 030220 oncology & carcinogenesis Meta-analysis Drug Discovery Medicine International Prostate Symptom Score business Urtica dioica |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines. 13:143 |
| ISSN: | 0189-6016 |
| DOI: | 10.4314/ajtcam.v13i2.17 |
| Popis: | Background: Urtica dioica is extract from the root of a stinging nettle. Materials and Methods: We carried out a systematic review and meta-analysis to assess the efficacy and safety of Urtica dioica for treating Benign prostatic hyperplasia (BPH). A literature review was performed to identify all published randomized double-blind, controlled trials of Urtica dioica for the treatment of BPH. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated. Results: Five publications involving a total of 1128 patients were used in the analysis. Primary efficacy end points: the international prostate symptom score (IPSS) (the standardized mean difference (SMD) =-10.47, 95% confidence interval (CI) =-18.12 to -2.82, p=0.007); the peak urinary flow rate (Qmax) (SMD=4.37, 95%CI=1.55 to 7.19, p=0.002) and prostate volume (SMD=-3.63, 95%CI=-4.67 to -2.57, p＜0.00001) indicated that Urtica dioica was more effective than the placebo or controls. Safety assessments included prostatic specific antigen (PSA) (SMD=-0.08, 95%CI=-0.23 to 0.07, p=0.31) showed that PSA levels were unaffected in both groups. Conclusion: This meta-analysis indicates that Urtica dioica to be an effective and safe treatment for LUTS associated with BPH. |
| Databáze: | OpenAIRE |
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