Synthesis of [13C2]-amitriptyline, nortriptyline and desmethylnortriptyline
| Autor: | I. Midgley, R. W. Pryor, D. R. Hawkins |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Chemistry Organic Chemistry Ring (chemistry) Biochemistry Medicinal chemistry Analytical Chemistry chemistry.chemical_compound Bromide Drug Discovery medicine Antidepressant Radiology Nuclear Medicine and imaging Amitriptyline Nortriptyline Amitriptyline+Nortriptyline Spectroscopy medicine.drug Tricyclic |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 15:511-521 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580150159 |
| Popis: | The syntheses of the antidepressant drug, amitriptyline, and its metabolites nortriptyline and desmethylnortriptyline, doubly labelled with carbon-13 have been accomplished in thirteen stages. Ba13CO3 was used for the carbonation of o-tolylmagnesium bromide, which subsequently provided a 13C-label distributed between positions 5, 10 and 11 in the tricyclic ring. A second carbon-13 atom was introduced at the terminal side-chain carbon, adjacent to nitrogen, using Na13CN. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text