Vitiligo evidence-based expert consensus recommendations for paediatric and adolescent patients: part I—topical therapeutics
| Autor: | Yael Renert-Yuval, Khaled Ezzedine, Pearl Grimes, David Rosmarin, Lawrence Eichenfield, Leslie Castelo-Soccio, Victor Huang, Seemal R Desai, Samantha Walsh, Jonathan I Silverberg, Amy S Paller, Mark Weingarten, Shanthi Narla, Jackie Gardner, Michael Siegel, Nanette B Silverberg |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | British Journal of Dermatology. 188 |
| ISSN: | 1365-2133 0007-0963 |
| Popis: | No United States paradigm for the treatment of paediatric, adolescent and young adult vitiligo has been developed. To develop evidence and consensus-based expert opinion to promote therapeutic consistency for the diagnosis and treatment of vitiligo. An IRB-exempted process was developed to produce consensus recommendations based on literature review and SORT criteria. Research questions were reviewed on 9 May 2022 in a video-based conference. Forty-two recommendations were made on the diagnosis of vitiligo (5) and optimal topical therapeutics (37). Topical calcineurin inhibitors, topical corticosteroids and topical ruxolitinib 1·5% cream were all identified as potential first-line therapies in the management of paediatric and adolescent patients with specific guidance on age-based data, frequency of application, minimum length of the therapeutic trial and coordinated usage of ultraviolet light therapy. The literature on paediatric and adolescent vitiligo has a heterogeneous methodology and lack of patient-reported outcomes. Children with vitiligo may be effectively managed with a variety of topical agents as first- and second-line therapy. Evidence supports the utility of topical calcineurin inhibitors, topical corticosteroids and topical JAK inhibitors, with limitations based on factors such as location, body surface area and age. |
| Databáze: | OpenAIRE |
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