Hydrogel scaffolds by self-assembly of a complementary ionic tetrapeptide
| Autor: | Federica Chiellini, Andrea Desii, Maria Rosaria Tine, Rossella Di Stefano, Roberto Solaro |
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| Rok vydání: | 2010 |
| Předmět: |
Scaffold
Materials science Polymers and Plastics Tetrapeptide Biocompatibility Organic Chemistry technology industry and agriculture Ionic bonding macromolecular substances Tissue engineering Self-healing hydrogels Polymer chemistry Materials Chemistry Self-assembly Minimally invasive procedures Biomedical engineering |
| Zdroj: | Journal of Polymer Science Part A: Polymer Chemistry. 48:986-990 |
| ISSN: | 0887-624X |
| DOI: | 10.1002/pola.23841 |
| Popis: | INTRODUCTION Various hydrogel materials have been developed for use as delivery vehicles of bioactive molecules and cells in tissue engineering. In this respect, injectable hydrogel materials, which can gel under physiological conditions, hold great potential. Injectable materials eliminate the need of complicated surgery for implantation, which allows minimally invasive procedures for tissue repair. Cells and bioactive factors can be incorporated easily in the system and injected to the defect site. Moreover, injectable hydrogels can take the shape of the defect to be regenerated, thus eliminating the need for precise prefabrication of the scaffold. Both hard and soft tissues may be targeted depending on the hardening mechanism. In general, in situ crosslinking leads to stiff materials, whereas self-assembly gives weaker systems that are, however, less toxic because of the lack of solvents and initiators. |
| Databáze: | OpenAIRE |
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