Verursacht die Infusion oder Inhalation von Prostaglandin-Trägerlösungen (Äthanol, Glycin-Puffer) pulmonalvaskuläre oder respiratorische Effekte?
| Autor: | M. Winterhalter, S. Piepenbrock, C. Weilbach, M. Bund |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Ethanol Inhalation Hemodynamics Oxygenation Pharmacology chemistry.chemical_compound medicine.anatomical_structure chemistry Glycine Vascular resistance medicine Breathing lipids (amino acids peptides and proteins) Respiratory system circulatory and respiratory physiology |
| Zdroj: | Pneumologie. 61:721-724 |
| ISSN: | 1438-8790 0934-8387 |
| DOI: | 10.1055/s-2007-980119 |
| Popis: | BACKGROUND Infusion or inhalation of prostaglandins PGE1 and PGI2 is used to reduce vascular resistance. PGE1 and PGI2 are dissolved in ethanol and glycine buffer, respectively. Each vehicle may cause dose-dependent haemodynamic and respiratory side effects. This study was performed to examine the role of low-dose ethanol and glycine buffer as used for the infusion and inhalation of PGE1 and PGI2. METHODS Two groups of pigs (ethanol and glycine group, n = 9 each) were anaesthetised and ventilated mechanically. Ethanol was given at 0.14 mg/kg/min by infusion and 0.12 mg/kg/min as aerosol, glycine buffer was infused at 3.8 microg/kg/min and inhaled at 3.1 microg/kg/min, respectively. Haemodynamic and respiratory data were recorded before and after application. RESULTS Neither infusion nor inhalation of ethanol or glycine buffer caused significant changes in systemic and pulmonary haemodynamics, right heart function, oxygenation or ventilation. CONCLUSIONS The effect of inhaled or intravenously infused PGE1 and PGI2 is not influenced by their preparations containing ethanol or glycine buffer. |
| Databáze: | OpenAIRE |
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