Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives

Autor:	Reddymasu Sreenivasulu, T. Yakantham, Rudraraju Ramesh Raju
Rok vydání:	2019
Předmět:	010405 organic chemistry Aryl General Chemistry Carbon-13 NMR 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Design synthesis Mass spectrum medicine MTT assay Human cancer Etoposide Amine derivatives medicine.drug
Zdroj:	Russian Journal of General Chemistry. 89:1485-1490
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363219070181
Popis:	A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.
Databáze:	OpenAIRE
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