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Basic Assumptions. The organizational hypothesis of sexual differentiation proposed by Phoenix, Goy, Gerall, and Young (1959) set the stage for research establishing that gonadal hormones permanently alter the expression of reproductive physiological and behavioral processes. It distinguished between two modes of steroid hormone action: activational or transient and organizational or permanent consequences on brain action. Organizational effects of hormones were restricted to fetal and neonatal developmental periods, whereas activational effects occur at any time after birth. |
