Two dpa-based zinc(ii ) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies
| Autor: | Yong-Po Zhang, Jin-Zhong Zhao, Jing-Yuan Xu, Zhong-Ying Ma, Chun-Yan Gao, Xin Qiao, Wen Gu, Shi-Ping Yan, Jin-Lei Tian, Xin Liu |
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| Rok vydání: | 2016 |
| Předmět: |
Nuclease
biology 010405 organic chemistry Chemistry Stereochemistry chemistry.chemical_element General Chemistry Zinc Cell cycle 010402 general chemistry Ligand (biochemistry) biology.organism_classification 01 natural sciences Molecular biology Catalysis 0104 chemical sciences HeLa Apoptosis Annexin Materials Chemistry biology.protein Cytotoxicity |
| Zdroj: | New Journal of Chemistry. 40:7513-7521 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c6nj00346j |
| Popis: | Two new mononuclear zinc(II) complexes [ZnLX2]2·CH3OH (X = Br for 1, Cl for 2) of a tridentate polypyridyl ligand L (L = 4-methyl-N,N-bis(pyridin-2-ylmethyl)aniline) have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA, pBR322 plasmid DNA and BSA have been explored respectively by using various physico-chemical techniques. Furthermore, the anticancer activities of the complexes towards three human tumor cells lines (HeLa, MCF-7 and RL952) have been studied. The IC50 values of 1 (on MCF-7 cells) and 2 (on RL952 cells) are 12.58 μM and 11.71 μM, respectively. The apoptosis-inducing activity of 1 was assessed by Hoechst 33342 staining, Annexin V binding and cell cycle analyses. |
| Databáze: | OpenAIRE |
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