| Autor: |
R. B. Bolin, G. A. Jamieson, T. Okumuru |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
VIth International Congress on Thrombosis and Haemostasis. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0039-1680555 |
| Popis: |
A tendency towards hemorrhage can occur in patients with myeloproliferative diseases and in many patients abnormal platelet function can be detected by various techniques. Platelet aggregation studies have shown decreased response to aggregating agents and a few patients may have no response to ADP, collagen and epinephrine and thus may mimic the platelet defect seen in patients with thrombasthenia. We have studied membrane glycoprotein patterns in 16 patients with various myeloproliferative disorders and compared the results to normal controls since glycoproteins have been implicated as being important to platelet function both in normal and pathological states. Although no abnormal glycoproteins were present, there was an abnormal ratio compared to the controls with a relative decrease in glycoprotein I (M. W. 150,000) and an increase in glycoprotein TV (M. W. 87,000) that was statistically significant (α0.005) . There was no discernible correlation between glycoprotein pattern and aggregation response or platelet count but those patients with megathrombocytes did have higher values for glycoprotein IV than those without megathrombocytes. These experiments suggest that patients with myeloproliferative disorders may have alterations in membrane glycoproteins that could alter platelet function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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