Adenovirus surveillance on children hospitalized for acute lower respiratory infections in Chile (1988-1996)

Autor: Luis F. Avendaño, Eliecer Villagra, Carmen Larrañaga, Adriana E. Kajon
Rok vydání: 2000
Předmět:
Zdroj: Journal of Medical Virology. 60:342-346
ISSN: 1096-9071
0146-6615
DOI: 10.1002/(sici)1096-9071(200003)60:3<342::aid-jmv14>3.0.co;2-0
Popis: Adenoviruses (Ad) play an important role in the etiology of acute lower respiratory tract infections (ALRI) in young children in Chile. Our aim was to correlate the clinical severity of the infections with the Ad strains isolated during surveillance over 8 years. From 1988 through 1996, nasopharyngeal aspirates (NPA) were obtained for viral isolation and immunofluorescence assay (IFA) from children under 2 years of age hospitalized for ALRI; Ad isolates were further studied by restriction enzyme analysis of genomic DNA. Of 3,097 cases enrolled, the Ad isolation rate was 12.6%. The most common admission diagnoses among Ad-positive cases were pneumonia and wheezing bronchitis (69.8%). Duration of Ad shedding was studied in 74 cases by IFA. Children excreting Ad for 4 or more days had a longer hospital stay than those shedding for 1-3 days (mean: 16.8 and 7.2 days, respectively; P
Databáze: OpenAIRE
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