Catalytic fluorination of trichloroethene by anhydrous hydrogen fluoride in the presence of fluorinated chromia under static conditions. Synthesis of [18F]-labelled CF3CH2F and [36Cl]-labelled CF3CH2Cl. Catalytic dehydrofluorination of CF3CH2F and CF3CH2Cl

Autor:	Alan W. Baker, William D. S. Scott, Irene Nicol, Scott John David, Watson Michael John, Geoffrey Webb, John M. Winfield, David William Bonniface, Ronald R. Spence, Thomas M. Klapötke
Rok vydání:	2000
Předmět:	Chemistry Organic Chemistry Inorganic chemistry Ab initio Hydrogen fluoride Biochemistry Chromia Amorphous solid Catalysis Inorganic Chemistry chemistry.chemical_compound Phase (matter) Anhydrous Environmental Chemistry Physical and Theoretical Chemistry
Zdroj:	Journal of Fluorine Chemistry. 102:279-284
ISSN:	0022-1139
Popis:	Catalytic fluorination of trichloroethene by anhydrous hydrogen fluoride at 653 K in the presence of fluorinated amorphous chromia under static conditions leads to a mixture of products in which partially halogenated olefins predominate. These are converted to mixtures containing CF3CH2F and CF3CH2Cl by a second fluorination using fresh catalyst. The results of product analyses from reactions carried out under various conditions have been used to design a synthesis of [18F]-CF3CH2F from CCl2CHCl. It is proposed that [18F] labelling occurs via direct [18F]- for [19F] exchange rather than by a dehydrofluorination/hydrofluorination route. [36Cl]-labelled CF3CH2Cl is readily prepared from CF3CH2F and H36Cl in the presence of chromia catalysts. Enthalpies of dehydrofluorination of CF3CH2F and CF3CH2Cl in the vapour phase have been computed. 1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2859a5c22648d96469fd042db45a9d66 https://doi.org/10.1016/s0022-1139(99)00289-4 Zobrazit plný text záznamu Full Text from ScienceDirect