ChemInform Abstract: Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones

Autor:	Jean Martinez, Jean-Alain Fehrentz, Laurent Gouilleux, F. Winternitz
Rok vydání:	2010
Předmět:	Carbamate medicine.medical_treatment General Medicine chemistry.chemical_compound Solid-phase synthesis chemistry Phase (matter) Anthranilic acid medicine Quinazoline Organic chemistry Hydroxymethyl Polystyrene Linker
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199710133
Popis:	The synthesis of chiral 3-substituted quinazoline-2,4-diones was performed starting from N-urethane anthranilamides. This synthetic pathway was applied in solid phase, from commercially available anthranilic acid that was bound to hydroxymethyl polystyrene resin via a carbamate linker. In both cases, cyclisation occurred under basic conditions to afford non-racemized quinazolinediones in high purity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::28591b8898bf31f14baa3414582d71ec https://doi.org/10.1002/chin.199710133 Zobrazit plný text záznamu Plný text