A concise synthesis of HIV integrase inhibitors bearing the dipyridone acid motif

Autor:	Rachel L. Eastwood, Barber Christopher Gordon, Kerry A. Paradowski, Michelle Y. Platts, David R. Fenwick, Jean-Yves Chiva, David C. Blakemore
Rok vydání:	2011
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Drug Discovery biology.protein HIV Integrase Inhibitors Regioselectivity Structural diversity Biochemistry Integrase
Zdroj:	Tetrahedron Letters. 52:512-514
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2010.11.112
Popis:	An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2858c4ff873f556b5af9f19b5c1872b3 https://doi.org/10.1016/j.tetlet.2010.11.112 Zobrazit plný text záznamu Full Text from ScienceDirect